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On 28 May 2024, enrolment in phase III clinical trials for sozinibercept in neovascular age-related macular degeneration (nAMD) was completed.1 These trials include two large multicentre, double-masked, randomized controlled trials (RCTs): COAST (OPT-302 with aflibercept in neovascular age-related macular degeneration; ClinicalTrials.gov identifier: NCT04757636) and ShORe (OPT-302 with ranibizumab in neovascular age-related macular degeneration; ClinicalTrials.gov identifier: NCT04757610).2,3 These trials represent one of the largest phase […]

Arshad Khanani, ARVO 2022: RGX-314 gene therapy for neovascular age-related macular degeneration

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Published Online: Jun 27th 2022

An overview and the mechanism of action of RGX-314 is discussed in this touchOPHTHALMOLOGY interview with Prof. Arshad Khanani (Sierra Eye Associates, Reno, NV, USA) as well as the limitations of anti-VEGF therapy for neovascular AMD.

The presentation entitled ‘Suprachoroidal Delivery of RGX-314 Gene Therapy for Neovascular AMD: The Phase II AAVIATE™ Study’ was presented at the The Association for Research in Vision and Ophthalmology, May 01-04, 2022.

Questions:

  1. What are the limitations of anti-VEGF therapy for neovascular AMD?
  2. What is RGX-314 and what is its mechanism of action?

Disclosures: Arshad Khanani is a consultant for Regenxbio and discloses grant/research Support from Regenxbio.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Shanice Allen.

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