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Corneal ectatic disorders, such as keratoconus, progressively weaken corneal integrity, leading to thinning, irregular astigmatism and visual deterioration.1 Typically progressive in nature, these ectasias result in increasingly thinner corneas, causing the cornea to protrude forward into a cone shape. This leads to increasing amounts of myopia and astigmatism – both regular and irregular – as the disease […]

EUROPEAN OPHTHALMIC REVIEW SUPPLEMENT 1 – 2017

Understanding the severity of keratitis and its impact in severe dry eye disease The target mechanisms that drive the pathophysiology of dry eye disease (DED) are principally tear film instability, tear hyperosmolarity, apoptosis and inflammation. These factors, respectively, lead to cell damage, nerve stimulation, cytokine release, matrix metalo-proteinase activation and goblet cell loss and form […]

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