At ASCRS 2026, 36-month data from the first-in-human study of the OmniVu Lens System suggest that modular shape-changing intraocular lens (IOL) technology may deliver a durable solution for presbyopia correction following cataract surgery.1
Presented by Dr William Wiley, the prospective, open-label, multicentre study enrolled 10 patients (14 eyes) aged 60–87 years undergoing phacoemulsification with OmniVu implantation. Patients were followed for 36 months, with outcomes including visual acuity across distances and refractive stability.2
Top-line summary
What’s new here?
This 36-month study demonstrates that the OmniVu modular shape-changing IOL provides stable refractive outcomes and a continuous range of vision from distance to near. The results confirm the long-term durability of the lens’s shape-changing mechanism, maintaining high patient satisfaction and excellent visual acuity without significant refractive drift.
What are the key data?
In a study of 10 patients followed for 36 months, the modular shape-changing IOL demonstrated stable refractive outcomes, with mean MRSE remaining within ±0.50 D and mean refractive cylinder between -0.50 D and -1.00 D. At 36 months, mean binocular uncorrected visual acuities were 20/17 for distance, 20/18 for intermediate, and 20/26 for near. With correction, binocular visual acuities reached 20/14 for distance, 20/15 for intermediate, and 20/20 for near, confirming the long-term durability and effectiveness of the shape-changing mechanism.
Implications for clinical practice
Modular shape-changing intraocular lenses may offer a durable, long-term solution for maintaining stable refraction and providing a continuous range of vision following cataract surgery. This technology could potentially mitigate presbyopia by preserving excellent distance and intermediate acuity while sustaining improvements in near vision for at least 36 months.
Sustained refractive stability and visual performance
The data demonstrate consistent refractive predictability over time, with mean MRSE remaining within ±0.50 D from 6 to 36 months and refractive cylinder maintained between −0.50 and −1.00 D. This stability is notable given historical challenges with effective lens position and refractive drift in presbyopia-correcting IOLs.
Visual outcomes at 36 months were strong across all focal distances. Binocular uncorrected visual acuity reached 20/17 for distance, 20/18 for intermediate, and 20/26 for near, with corrected acuities improving further to 20/14, 20/15, and 20/20, respectively. These findings support the lens’s ability to deliver a continuous range of vision from far to near.
Mechanistic durability and quality of vision
The results demonstrate the long-term durability of the lens’s shape-changing mechanism, with no meaningful decline in performance over three years. Investigators also reported early contrast sensitivity outcomes comparable to monofocal IOL benchmarks, an important consideration given the trade-offs often associated with presbyopia-correcting technologies.
Low rates of YAG capsulotomy and stable lens positioning were also highlighted as differentiating features, suggesting the platform may address some of the longstanding limitations of existing lens designs.
Implications for clinical practice
These findings indicate that modular shape-changing IOLs could offer a meaningful step forward in cataract and refractive surgery, combining refractive stability with a full range of vision. If replicated in larger studies, this technology may reduce the need for compromise between distance, intermediate, and near outcomes, while providing a more durable approach to presbyopia correction.
In practical terms, this could translate into greater confidence for surgeons and more consistent visual outcomes for patients over the long term.
References:
- Atia Vision Announces Durable 36-Month Results from First-in-Human Study of their Dynamic Shape-Changing OmniVu Intraocular Lens System. Businesswire. Available at: https://www.businesswire.com/news/home/20260414715175/en/Atia-Vision-Announces-Durable-36-Month-Results-from-First-in-Human-Study-of-their-Dynamic-Shape-Changing-OmniVu-Intraocular-Lens-System (accessed 23 April 2026).
- Wiley WF. Durability of Visual and Refractive Outcomes with a Modular Shape-Changing IOL. Presented at: ASCRS 2026 Annual Meeting. Available at: https://ascrs.confex.com/ascrs/26am/meetingapp.cgi/Paper/122532
Citation: ASCRS 2026: OmniVu shape-changing IOL shows sustained performance at 36 months. touchOPHTHALMOLOGY. 23 April 2026.
Disclosure: This article was created by the touchOPHTHALMOLOGY team utilizing AI as an editorial tool (ChatGPT (GPT-5.4) [Large language model]. https://chat.openai.com/chat.) The content was developed and edited by human editors. No funding was received in the publication of this article.
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