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On 28 May 2024, enrolment in phase III clinical trials for sozinibercept in neovascular age-related macular degeneration (nAMD) was completed.1 These trials include two large multicentre, double-masked, randomized controlled trials (RCTs): COAST (OPT-302 with aflibercept in neovascular age-related macular degeneration; ClinicalTrials.gov identifier: NCT04757636) and ShORe (OPT-302 with ranibizumab in neovascular age-related macular degeneration; ClinicalTrials.gov identifier: NCT04757610).2,3 These trials represent one of the largest phase […]

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Michael Boland, MD, AGS 22: Measuring Disease Progression in Clinical Trials

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Published Online: Mar 29th 2022

It was a pleasure to speak with Prof. Michael Boland (Massachusetts Eye and Ear, Boston, MA, USA) about methods used to measure disease progression in glaucoma.

The presentation entitled ‘Measuring Disease Progression in Clinical Trials’ was presented at the 2022 American Glaucoma Society Annual Meeting, March 03-06, 2022.

Disclosures: Michael Boland is a consultant for Carl Zeiss Meditec, Topcon and Allergan

Questions:

  1. What is the limitation of using intraocular pressure (IOP) as the only outcome measure in clinical trials for glaucoma therapies? (00:21)
  2. What other methods can be used to measure disease progression in glaucoma? (01:09)

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Shanice Allen.

Filmed in coverage of the virtual AGS 2022.

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