US OPHTHALMIC REVIEW – VOLUME 11 – ISSUE 2 – FALL 2018

  Welcome to the fall edition of US Ophthalmic Review, which features a wide range of articles that reflect the remarkable advances in ophthalmology in recent years. Our expert interviews continue to be a popular feature of the journal, providing concise opinions from ophthalmic specialists. Cynthia Matossian discusses testing for biomarkers for Sjögren’s disease in […]

Q. Can you tell us about the latest research into testing for biomarkers for Sjögren's disease in patients with dry eye disease that does not improve with standard therapy? Many patients who have dry eye disease could also have Sjögren's disease because the symptoms of Sjögren's disease vary. Patients might be reporting dental decay to […]

Q. What are the major unmet needs in the treatment of nAMD? There are three major areas of unmet need. The first is improved efficacy in the short term, then increased durability of treatment, and finally maintenance and even improvement of efficacy in the long term. A drug or device that could address one of […]

One of the most important differential diagnoses in the pediatric retina population is retinoblastoma. A detailed history, good eye examination, good ultrasonography, and any other ancillary tests are essential for making the correct diagnosis. Retinoblastoma is the most common primary ocular tumor in pediatric patients. The incidence accounts for 1 in 20,000 live births and […]

Retinoblastoma is a primary intraocular cancer that develops in the eyes of children. The vast majority of retinoblastoma tumorigenesis is initiated by a mutation in the RB1 gene on chromosome 13q,1 which was the first tumor-suppressor gene described. Retinoblastoma is a rare disease occurring in approximately one in 18,000 live births annually and can affect […]

Uveitis comprises a range of intraocular inflammatory conditions of both infectious and non-infectious origin that can result in irreversible ocular damage and impaired vision or blindness.1 Effective management is therefore vitally important to prevent ocular damage and preserve visual acuity and quality of life.1–3 Therapeutic management of uveitis is dictated by etiology and anatomic location.1 […]

Nasolacrimal duct obstruction (NLDO) is common in the pediatric population. The anatomic location of obstruction may be either pre- or post-saccal. It is typically congenital and occurs due to the persistence of a membrane at the level of the valve of Hasner in the distal nasolacrimal duct.1 Other causes include post-traumatic obstruction of the lacrimal […]

In 2015, a novel imaging technology called optical coherence tomography angiography (OCTA) became available for clinical use. The features of many disorders, including diabetic retinopathy (DR), choroidal neovascularization (CNV), macular telangiectasia type 2, retinal vascular occlusion, and sickle cell retinopathy have been characterized by OCTA. OCTA is a non-invasive, non-dye-based imaging technique that employs motion […]

Over the past 45 years, vitreoretinal surgery has evolved considerably. In 1972, Machemer et al. introduced the concept of pars plana vitrectomy with a 17-gauge vitreous cutter.1 Today, retinal surgeons have access to a wide variety of instruments as small as 27-gauge for micro-incision vitrectomy surgery. Progress has occurred not only in vitrectomy probes, which […]