Ocular Surface Disease

Dry eye disease (DED) is a prevalent ocular condition characterized by discomfort, visual disturbances and tear film instability due to insufficient tear production or rapid tear evaporation.1 With an increasing global incidence (i.e. up to 50%) and its significant impact on the quality of life, there is a growing need for accurate and efficient diagnostic methods to […]

Dry eye disease (DED) is a multifactorial condition of the ocular surface and tears. It is frequently encountered in ocular practices, comprising nearly 33% of visits in the USA, and with an estimated global prevalence ranging between 5% and 50%.1,2 The chronic symptoms and discomfort reported by patients with DED directly impact their quality of life […]

Reproxalap is a reactive aldehyde species (RASP) inhibitor believed to mitigate inflammatory conditions such as dry eye disease (DED), allergic conjunctivitis and uveitis.1 RASP are pro-inflammatory molecules that covalently bind to thiol and amino groups expressed on various receptors and kinases. This binding activates the pro-inflammatory signalling cascade, which involves the activation of inflammatory cytokines leading to inflammation and pro–histaminic factors leading to an allergic response.1 Malondialdehyde (MDA) […]

Demodex blepharitis is a highly prevalent lid margin disease that is commonly missed or misdiagnosed by eye care professionals. The disease is caused by an infestation of Demodex mites – tiny parasites that live in the eyelash follicles and feed on oily sebum. When present in small numbers, the effects of these mites are subclinical and are likely […]

The prevalence of both dry eye disease and sleep apnoea has steadily increased in the USA.1 Importantly, new research reveals the need for multispecialty collaboration based on evidence that patients may be at risk for eye irritation secondary to airflow from mask leakage or retrograde nasolacrimal air escape.2 Sleep apnoea and ocular disorders Sleep apnoea is […]

Dry eye disease (DED) is an inflammatory condition of the cornea and conjunctiva that is characterized by tear-film instability and increased tear osmolarity.1–3 While DED is traditionally viewed as a chronic condition, many patients experience episodic exacerbations of the disease, also referred to as flares or episodic dry eye.1 Until recently, the need for an effective treatment […]

Over the past few years, we have witnessed an increasing awareness of the importance of treating ocular surface disease (OSD). Diagnoses such as dry eye and blepharitis, which were historically under-appreciated, now command attention from the ophthalmologist and investment from the ocular pharmaceutical industry. Proper treatment of the ocular surface is paramount to the health […]