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On 28 May 2024, enrolment in phase III clinical trials for sozinibercept in neovascular age-related macular degeneration (nAMD) was completed.1 These trials include two large multicentre, double-masked, randomized controlled trials (RCTs): COAST (OPT-302 with aflibercept in neovascular age-related macular degeneration; ClinicalTrials.gov identifier: NCT04757636) and ShORe (OPT-302 with ranibizumab in neovascular age-related macular degeneration; ClinicalTrials.gov identifier: NCT04757610).2,3 These trials represent one of the largest phase […]

Ramin Khoramnia, WOC 2020 – STAIRWAY Phase 2 Trial

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Published Online: Jul 31st 2020

Ramin Khoramnia (University Eye Clinic Heidelberg, Heidelberg, Germany) discusses imitations of current treatment options for neovascular age-related macular degeneration, gives an overview of faricimab, its dosing regimen and its mechanism of action and discusses the major efficacy and safety findings of the STAIRWAY study, which were presented at WOC 2020.

1. What are the limitations of current treatment options for neovascular age-related macular degeneration? (0:05)
2. Could you give us an overview of faricimab, its dosing regimen and its mechanism of action? (1:07)
3. What were the aims and design of the STAIRWAY study? (2:07)
4. What were the major efficacy and safety findings of this study? (2:54)

5. What is the potential for combining faricimab with angiopoietin-2 and vascular endothelial growth factor inhibitors and what future studies are planned? (3:33)

Disclosures: Ramin Khoramnia has received grant support from: Alimera, Bayer, Chengdu Kanghong, Novartis, and Roche; travel support from: Alimera, Allergan, Bayer, Novartis, and Roche; and lecture fees from: Alimera, Allergan, Bayer, Novartis, and Roche.

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Commissioned, edited and funded by Touch Medical Media
Published: 31 July 2020

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